For the season on third downs, he's completing only 48.9% of his passes and owns a 78.0 passer rating. That would help against a Lions offensive line featuring three solid first-round picks in left tackle Taylor Decker (2016), center Frank Ragnow (2018) and right tackle Penei Sewell (2021). NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round Conference Championship Super Bowl hidden -- Adam Teicher, Bold prediction: Raiders cornerback Amik Robertson will have a takeaway against the Chiefs. NFL best bets and picks for Week 5: Take the 49ers and the points, and the Jets-Falcons over. Lions 28, Panthers 20 -- Michael Rothstein, This is the second of three consecutive road games for the Niners, and they're coming off a trio of games they lost by a combined eight points. The Steelers' 2022 quarterback journey, and what happens next, What to watch for: The Patriots have given up 325 rushing yards on 51 carries (6.37 on average) over their past six quarters, while the Lions rank first in the NFL in average yards per rush (5.9) and sixth in total rushing yards per game (164). Buffalo is at least a three-point underdog on the road, suggesting this could be a trap game for the Bills after big wins over Denver and Atlanta. -- Paul Gutierrez. ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. Stat to know: Trevor Lawrence struggles under pressure, having the largest drop-off of any QB in QBR (-76) compared to when he's not pressured. ET | Fox The Raiders . The 61-0 streak is over: Why the Ravens are no longer the NFL's best closers, Monday 8:15 p.m. Let's get into the full Week 5 schedule, starting with an NFC South showdown. Is Jalen Hurts' breakout legit? New England's slide has coincided with losing DT Lawrence Guy (shoulder), who might be ready to return. Experts weigh in with analysis and provide premium picks for upcoming NFL games. NFL Nation reporters predict the outcomes and scores for Sunday's and Monday's Week 5 games. The Rams took their first loss, and the. Cowboys' running game will be tested on Sunday (1:06) Herm Edwards and Tedy Bruschi discuss the outcome of what could be a high-scoring game in Dallas. Just ask Tampa Bay Buccaneers fans, or Buffalo Bills fans, or Seattle Seahawks fans, or the defense of the Dallas Cowboys.. 1-ranked run defense to power the Browns to their second win on Monday Night Football this season. If the Titans can't run, they are in trouble against the Dolphins, especially with the uncertainty of Mariota (hamstring). -- Rob Demovsky, Bold prediction: Aaron Rodgers throws for 300-plus yards and at least three touchdowns. ESPN Fantasy's Kyle Soppe and ESPN Chalk's Mackenzie Kraemer hand out helpful nuggets as well. Stat to know: The Chiefs have won six straight home games on Monday Night Football with the last loss coming in 2004 against the Patriots. Chicago knows how dangerous Minnesota's run game can be, so they'll stack the box to try to take away Dalvin Cook and make Cousins beat them with his arm. Betting nugget: The Broncos are 1-7 ATS in their past eight games. Markquese Bell capitalizing on Cowboys opportunity, The 61-0 streak is over: Why the Ravens are no longer the NFL's best closers, Raiders, Josh McDaniels savor first win vs. division rival, former employer Broncos, Mahomes' 'Houdini' play leads Chiefs' bounce-back, Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs, Patrick Mahomes says Andy Reid 'stole the show' in TV ad, Ranking early-season NFL award front-runners: Barnwell picks MVP, OPOY, DPOY, top rookies, 'Believe in yourself': Inside Kelly Kleine's historic rise to executive director of Broncos' football ops, Are the Broncos concerned about Russell Wilson? Jets 20, Browns 17 -- Rich Cimini, Old friend Josh McCown is healthy and completing 70 percent of his passes, and the Jets have won two in a row with the kind of run-pass balance that the Browns should study. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. Walder's pick: 49ers 23, Panthers 14 See Week 5 rankings. Betting nugget: In the past six London games, favorites are 5-1 ATS, and five of the six games went under the total. Listed at 5-foot-8, 187 pounds, he stood tall against Denver last week with a 68-yard scoop-and-score TD and played tough defense against Jerry Jeudy. Inside Jets' trade pursuit of Tyreek Hill, and how they rebounded Dolphins say QB Tua Tagovailoa ruled out for Week 5 game vs. New York Jets, What to watch for: Justin Herbert finished with 398 passing yards in the Chargers' win over the Browns last season, the most Cleveland surrendered in any game in 2021. Veteran WR Cole Beasley retires after 11 NFL seasons, What to watch for: Rookie quarterback Kenny Pickett is set to make his first career start against a Bills defense that is tied with the San Francisco 49ers for giving up the fewest yards per game (234.5). He needs nine receptions on Sunday to break the five-game record, held by Zach Ertz (2018) and Eric Johnson (2004). Stat to know: The 49ers are 0-2 and averaging 10.0 points per game on the road this season -- and 2-0, 25.5 PPG at home. Colts vs Broncos starts the week off on Thursday Night Football. Patrick Mahomes has been as good against the Raiders as any opponent, with a 7-1 record, 22 touchdowns and just three interceptions. The Carolina Panthers, with the No. -- Turron Davenport. What to know for fantasy: Pittsburgh's Diontae Johnson owns a 20.5% target share this season from Rudolph, up from his 9.7% rate with Ben Roethlisberger under center. The Vikings' passing game has been bad (169.0 yards per game), prompting receiver Adam Thielen to express his frustrations and, in turn, Cousins to apologize. Matchup rating: 49.4 | Spread: LAC -6.5 (44.5), What to watch for: With Denver desperate for a win and fellow edge rusher Bradley Chubb done for the year because of an ACL injury, look for Von Miller to ignite the Broncos by getting after Philip Rivers, who has limited mobility. Betting nugget: Since the start of the 2016 season, Arizona is 3-13 ATS in 1 p.m. This is the second-longest current home losing streak in the NFL behind the Cardinals, who have dropped seven in a row at home. In three games against the Packers, including playoffs, Elliott has run for 157, 125 and 116 yards on 79 carries. Chuck Pagano has never started a season 1-4 as coach of the Colts. Colts 21, 49ers 17 -- Mike Wells, Marcus Mariota's playing status could be unknown until Sunday, but the Titans have problems to solve even if he does find a way to play. But this week, players and coaches have been quick to say that was one game and the Chiefs present a different challenge. -- Jeff Legwold. Betting nugget: Smith is 23-15 ATS in his career, including 10-2 ATS in his past 12 starts and 5-2 ATS with Seattle. Injuries: Eagles | Steelers. Betting nugget: Both times Rodgers faced the Cowboys in Dallas, Green Bay won the game outright as an underdog (2016 divisional round and 2017 Week 5). What to know for fantasy: Broncos receiver Courtland Sutton is on pace for 88 catches, 1,236 receiving yards and eight touchdowns. 1 min read. The offense remains a question mark, however, and could be without starting left tackle Rees Odhiambo because of a chest injury. -- DJ Bien-Aime. DAL-LAR | CIN-BAL | LV-KC, What to watch for: The Bucs are on a rare two-game slide and are 0-2 at home so far this season, while the Falcons have won two straight. NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. When the draft ended, there was a total of 43 trades, breaking . His five sacks this season match the total he recorded over the previous two seasons (21 games) combined. That doesnt mean theyll have an easy time against Houston rookie QB Deshaun Watson. However, Indianapolis figures to be rocking as Peyton Manning is honored with a statue, and mobile signal-callers like Jacoby Brissett have helped mitigate some of San Francisco's pass-rush ability. The Week 5 NFL slate is stacked with great matchups. Things are lined up -- on paper at least -- for the 49ers to get their first victory of the season. They'll do just enough to keep things that way. play. They also rank No. If the Jaguars have the same kind of issues along the defensive front they did last week, it'll be another long day. -- Nick Wagoner, Embracing the fun spirit of fantasy sports, ESPN senior fantasy analyst Matthew Berry and his unconventional cast of characters aim to make fantasy football players smarter and help them win their leagues. Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . See Week 5 rankings. This one could be decided by which quarterback is upright at the end of the afternoon. ET | Fox What to know for fantasy: Curtis Samuel's target share is nearly twice that of DJ Moore (24.1% to 12.1%) with Kyle Allen under center for the Panthers this season. What will help you is the fact that the GOAT is averaging 28.0 PPG as a Buccaneer against the Falcons. Stat to know: JuJu Smith-Schuster's 15 receiving yards against the Bengals were the fewest he has had in a regular-season game in which he registered at least one reception. Read more. Chicago head coach Matt Nagy is high on veteran backup quarterback Chase Daniel, who's starting in place of Mitchell Trubisky (left shoulder), but Nagy still wants to control the clock and pound the ball with Montgomery. Also note that the Redskins enter the game ranked 29th in rushing yards allowed per game (147.5). He is seeing the most targets per route run (32.4%) among wide receivers this season. (1:06). ET | Fox CFB: The way-too-early top 25 for 2021 DET-NE | CHI-MIN | MIA-NYJ The Cowboys will be the third pass defense the Rams have faced so far ranked in the top seven, and their varied pass rush will make life difficult for Stafford. Reiss' pick: Patriots 30, Redskins 6 However, Arizona's primary hope for winning this game lies with its run defense. Read more. This feels like it could go either way, but the edge goes to the home team. Paired with fellow receivers John Brown and Jaron Brown, the Arizona wideouts pose a threat to a vulnerable Eagles cornerback group. What to know for fantasy: Dallas' Amari Cooper is on pace for a career-high 84 catches and has scored four times in four games this season. With Chris Carson gone, can Rashaad Penny 'take off' as Seattle Seahawks' RB1? Expect the Texans to feed the Jaguars a heavy dose of Pierce, especially with run-game anchor Foley Fatukasi dealing with a quad injury. "That's why he's one of the best [defensive] ends/outside 'backers ever." If that's the case, the Cardinals could pull off the upset. Here's how Week 5 is shaping up as we continue through the 2021 season CBSSports.com . Christian McCaffrey, the eighth pick, leads the NFL in rushing with 411 yards, and Jacksonville's Leonard Fournette, the fourth pick, isn't far behind with 404. Betting nugget: Last season, first-round quarterbacks making their first career starts went 0-5 ATS. At 0-4, the Browns talked a good game all week, but there was a feeling that folks were looking over their shoulder. That number is down to once every 34.8 passes this season, and he ranks as QB23 through Week 4. Betting nugget: Minnesota is 22-10-1 ATS after a loss under Mike Zimmer. Read more. It sounds crazy, but the Jets will win their third straight game. ET | NFL Network The Jags likely won't have cornerback Jalen Ramsey, and the domino effect of his absence will be a major issue when McCaffrey lines up on the outside. Read more. What to know for fantasy: Breece Hall has a touchdown or six catches in all four games this season and seems to be trending in the direction of a lineup lock. Moody's pick: Eagles 30, Cardinals 17 What to know for fantasy: Murray leads the NFL with 187 opportunities this season (pass-plus-rush attempts). Williams' pick: Chargers 27, Broncos 20 -- Jake Trotter, Bold prediction: The Chargers have yet to put together a 100-rushing yard performance this season, but that will change Sunday against the Browns. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score predictions. He will etch his name in the record books, joining Jim Brown in 1958 as the second player in league history to score multiple touchdowns in four of the team's first five games. -- Adam Teicher, To celebrate 100 years of pro football, Peyton Manning travels the country to see the people and places that made the NFL the NFL. Dolphins 19, Titans 17 -- Cameron Wolfe, The Dolphins allowed 235 rushing yards in last year's loss to the Titans. What to know for fantasy: DK Metcalf had the big Week 4, but Tyler Lockett has benefited most from the overachieving of Smith more than 75 receiving yards in three straight games. Stat to know: The Dolphins' 11-2 record since 2021 Week 9 is tied with the Chiefs for best in the NFL. His 43.1 QBR this season is also his worst through the first four games in that same time frame. With DT Fletcher Cox still working through a calf injury, there's a chance Palmer will have a little more time to operate. ET | FOX See Week 5 rankings. TB-NO | ATL-HOU | BUF-TEN Everything you need to know for the draft FPI prediction: JAX, 71.8% (by an average of 6.6 points), Matchup must-reads: Texans release starting TE Pharaoh Brown After loss, the Jaguars look to rebound against AFC South How LSU and the SEC prepared Texans rookie Derek Stingley Jr. for the NFL Former Jaguars QB Blake Bortles says he 'quietly' retired, What to watch for: Things have not being going well for Baker Mayfield. Theres not a whole lot of tape out there on Trubisky, which is a disadvantage for Minnesota in game planning. -- Ben Baby. Swift likely out again vs. Patriots, source says, What to watch for: The Vikings' defense has given up 1,054 passing yards this season, seventh-most in the NFL, as it meanders through the adjustment process to coordinator Ed Donatell's 3-4 scheme. The Raiders opened the season with three of their first four games on the road. Week 5 brings some more great matchups and potential upsets. Betting nugget: Both Allen and Gardner Minshew II are 3-0 ATS in their careers as starters. Stat to know: Allen has accounted for all 12 of the Bills' offensive touchdowns this season (either pass or scored). What to know for fantasy: T.J. Hockenson had 24.2 fantasy points through three weeks before exploding for a career-best 39.9 points last week against the Seahawks. Expect the Raiders' overachieving defense to make a play or two -- paging Khalil Mack and his four sacks -- to jump-start the offense, and all will be right in Silver and Blackdom for a week, at least. Last week, we hit the Falcons at +3. IND-KC | CLE-SF, 1 p.m. NFL expert picks, predictions, lines for Week 5 highlighted by the Giants at Green Bay, Dallas at the Rams, and Las Vegas at Kansas City NFL Expert Picks, Predictions: Week 5 * next to the pick means the team will win, but not cover. The Bills might be 3-1 and playing the 1-3 Bengals, but Vegas seems to like Cincinnati in this game. What to know for fantasy: Through four weeks, there were 44 players with at least 25 carries. The Bolts are averaging an NFL-low 64.5 rushing yards per game, while the Browns' defense is ranked 17th, allowing an average of 113 yards per game. Overall, Minnesota is tied for eighth in points allowed (19.0) and third in rushing yards allowed (71.3). HOU-JAX | SF-CAR | PHI-ARI ET | CBS The team that gets the running game going will have a decisive advantage. Commanders patient with Wentz despite rough stretch RB Robinson returns to practice after being shot in robbery attempt, What to watch for: Texans running back Dameon Pierce is coming off the first 100-yard game of his career (which included a 75-yard TD run) and ranks 10th in the NFL in rushing. Stat to know: According to NFL Next Gen Stats data, Aaron Rodgers ranked first in completion percentage into tight windows in 2016. The Bengals can build on their momentum here, and a win would make them 2-3 prior to their bye. The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Buccaneers coach Todd Bowles explains handling of TE Cameron Brate's concussion, Veteran WR Cole Beasley retires after 11 NFL seasons, QB Kenny Pickett, Steelers begin work to get on 'same page', The Steelers' 2022 quarterback journey, and what happens next, LB Jamie Collins joins Patriots for fourth time, Swift likely out again vs. Patriots, source says, Bears designate WR N'Keal Harry for return; OL Cody Whitehair headed to IR, Inside Kelly Kleine's historic journey, from Vikings to Broncos, Justin Fields, Bears' struggling passing game looking for answers, Vikings riding ups and downs as Cousins learns new scheme, Dolphins' Mike McDaniel not fretting criticism over Tua Tagovailoa, Inside Jets' trade pursuit of Tyreek Hill, and how they rebounded, Dolphins say QB Tua Tagovailoa ruled out for Week 5 game vs. New York Jets, Browns' schedule gets difficult from now on, Garrett back at Browns practice for first time since car crash, Everything you need to know for the draft, The Seahawks have needed every bit of Geno Smith's unlikely success, Andy Dalton gave Saints' offense a spark, but bigger issues loom after 1-3 start, Saints' Alvin Kamara (rib) expects to play against Seahawks, Titans rookie WR Treylon Burks exits game with leg injury, Rivera OK with 'frustrations' amid 1-3 start, Commanders patient with Wentz despite rough stretch, RB Robinson returns to practice after being shot in robbery attempt, After loss, the Jaguars look to rebound against AFC South, How LSU and the SEC prepared Texans rookie Derek Stingley Jr. for the NFL, Former Jaguars QB Blake Bortles says he 'quietly' retired, Jimmie Ward year away from being among rarefied 49ers company, Mayfield struggles, but Panthers don't have another option, Nick Bosa says 49ers' defense has personnel to be 'best in the league', Mayfield takes blame for offense's struggles amid 1-3 start, Darnold's return from IR not close, coach Matt Rhule says, Miles Sanders' emergence makes the Eagles so much better, Defense keeps Cardinals afloat while offense figures it out, Jerry Jones: An 'injustice' not to give coach McCarthy credit.