5.Children, preganant or lactation women,elderly ,feeble and weak patients ,spleen and stomach weakness patients should be taken under the guidance of physician. Unable to load your collection due to an error, Unable to load your delegates due to an error. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. Keyword Highlighting The treatment strategy of active intervention is put forward, which includes the treatment of both exterior and interior, the treatment of syndrome first, the treatment of disease cutting off, the overall adjustment, and multitarget treatment. According to the Cochrane Handbook bias risk assessment tool, bias risk is independently assessed. Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. Wang DC, Yu M, Xie WX, Huang LY, Wei J, Lei YH. In the analysis, we will exclude lower-quality trials and repeat the meta-analyses to examine whether the quality of included studies influences the pooled results. WebFor patients showing mild symptoms, Lianhua Qingwen would be more effective. This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, disappearance rate of cough symptoms, disappearance rate of asthenia symptoms, and adverse drug events. In addition, only studies published in English and Chinese will be searched and included because of language barriers, so a language bias may exist. It embodies the active therapeutic principles of clearing away plague and detoxification, releasing lung heat, and aromatizing dampness. In this study, 100 participants were How to Use: Dosage: Consume orally 4 capsules each, 3 times daily after meal. The PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) checklist of this protocol is presented in PRISMA-P checklist. WebDrug Name Lianhua Qingwen Capsules; Approval No. GYZZ Z20040063; Strength 0.35g/capsule; Administration and Dosage For oral administration, 4 capsules once, 3 A funnel plot will be constructed and examined to assess publication bias and possible small study biases if the group include more than 10 trials. It has important clinical application value to treat patients with covid-19. [1]. [Overview of Meta-analysis of Lianhua Qingwen preparations in treatment of viral diseases]. High-tech Demonstration Project of National Development and Reform Commission Nevertheless, this systematic view should help further expand our understanding of Lianhua Qingwen combined with conventional antiviral Western Medicine treatments in COVID-19 and asymptomatic infection. Methods: Before the evaluation results of this system are published, all databases will be retrieved again. XLZ and QZ will independently screen the potential studies and extract data. Receive exclusive coupons and special offers directly to your email inbox. For patients showing mild symptoms, Lianhua Qingwen would be more effective. HHS Vulnerability Disclosure, Help 13. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. High heterogeneity may also arise from the various evaluations. If I2 test 50%, a random-effects model will be used for data analysis instead. [21]. Objective: Copyright Shijiazhuang Yiling Pharmaceutical Co,Ltd. It is approved by HSA asan over-the-counter traditional Chinese medicine to treat influenza and colds. Hongtao Lei, Shutu Ma, Xiuxin Jiang, et al. Wu Yiling. To add, theonline sale and distribution ofthis productis prohibited and those engaging in this activityviolatethe R.A.10918orPhilippine Pharmacy Act. Before All reports of the randomized controlled trials (RCTs) on Lianhua Qingwen capsule treating influenza Post code: 050035 Tel: 0086-311-85901643 Fax: 0086-311-85906730 Website: http://www.yiling.cn Any questions or problems, please do not hesitate to contact manufacturer. Wu C, Chen X, Cai Y, et al. Preliminary study on the inhibitory effect of three prescriptions of traditional Chinese medicine on SARS related coronavirus in vitro [J]. You may be trying to access this site from a secured browser on the server. The data extraction form will include the following items: Two reviewers/authors (ZXL and ZQ) will independently evaluate the quality of the included trials through assessing the risk of bias using the following tools, when appropriate: The following aspects of included trials will be assessed: sequence generation, allocation concealment, blinding of participants, personnel and outcome assessors, incomplete outcome data, and selective outcome reporting. Announcement of the national health and Health Commission of the people's Republic of China [EB /OL] (2020-01-20) [20200217]. 2 capsules per dose. Avoid receiving nourishing Chinese medicine during the period in this product. Rappler.com. Please try again soon. Children, pregnant women, nursing mother, senile and infirm patients or those with week spleen should take medicine under doctors direction. As a drug, ephedrine is a decongestant and bronchodilator. Effectiveness and Safety of Lianhua Qingwen Capsules for COVID-19: A Propensity-Score Matched Cohort Study. Cao B, Zhang D, Wang C. A trial of lopinavir-ritonavir in, [6]. When you buyLHQW from us, actsmarket.com will donate the same number of boxes to needy seniors above 50 years old, living in 1-room or 2-room rental flats in Singapore, cap at 140 bundles or 700 boxes. A: Before treatment; B: After treatment. National Key New Product The secondary outcomes of this review will include antipyretic time, disappearance rate of fever symptoms, disappearance rate of cough symptoms, disappearance rate of asthenia symptoms, and adverse drug events. 15. [14]. The proportion of severe patients admitted to covid-19 hospital is 15.7%, and the death rate of confirmed patients is 6.7%. The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe. National Library of Medicine This review will be helpful to clinicians treating COVID-19 and asymptomatic infection may provide evidence for researchers. Nausea, diarrhea, vomiting, abdominal pain, dry mouth, rash, itching, dizziness. Among the many commonly used TCMs, the most commonly used one is Lian-Hua Qing-Wen Granule (LHQWG). Lianhua Qingwen formula is based on the theory of collateral disease, to reveal the law of transmission of respiratory infectious diseases caused by virus. official website and that any information you provide is encrypted Particularly, when ephedrine is combined with caffeine (coffee), itcan lead to significant cardiovascular, metabolic, and hormonal responses. However, this systematic review will have some limitations. A: CT at admission (February 14, 2020); B: CT Reexamination after treatment (February 25, 2020); C: CT Reexamination after treatment (March 13, 2020); D: CT Reexamination after discharge (June 11, 2020). The course of treatment is 7-10 days for patients with mild and moderate COVID-19. For oral use after meals,4 capsules thrice daily or by medical ordor5 boxes for a treatment course. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in [10]. Do not use this product if the property changed. All randomized controlled trials (RCTs), Retrospective cohort study (RCSs), Comparison before and after the study (BAs) of Lianhua Qingwen combined with Conventional antiviral Western Medicine for COVID-19 will be included. 9 Experimental research also showed that LH exerted broad-spectrum effects on a series of influenza viruses by inhibiting viral propagation and regulating immune function. The full text of articles potentially suitable for the review will be obtained for further assessing eligibility based on the inclusion criteria or/and exclusion criteria. Any disagreement will be resolved by consensus or discussion with a 3rd party (MJL). The abstracts of all studies will be independently screened by the review authors (XLZand QL). Consultancy by Fixx Digital > 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). It has become a representative Chinese patent medicine for public health emergencies of the respiratory system. 6.Patients with fever over 38.5 , should go to the hospital. Yizhu Wang, Hongtao Wang, Xue Han, et al. eCollection 2020. [8]. Copyright 2023 MIMS Pte Ltd. All rights reserved. MJL will arbitrate any disagreement and ensure that no errors occur during the review. Open the moisture-proof bag, please pay attention to prevent moisture. Avoid prolonged use. Two reviewers (XLZ and JNL) will assess the eligibility of the studies retrieved during the searches independently using the inclusion and exclusion criteria. [Package]Aluminium-plastic package, 24 capsules/box, [Executive Standard]Chinese Pharmacopoeia 2010, the 2nd supplemental volume. The registered Chinese capsule Lianhua Qingwen that has been approved should have the FDAs labeling requirements written in English, Domingo said. Chinese Journal of nosocomial infection 2015;25:7279. This systemic review will evaluate the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19. [Adverse Reactions]Post-marketing monitoring data show that this product may cause gastrointestinal adverse reactions such as nausea, vomiting, abdominal pain, diarrhea, bloating, as well as rash, itchy ulcers, dry mouth, dizziness. Pharmacological experiments have indicated that a high dosage of Lianhua Qingwen alters the effectiveness of cyclooxygenase-2 in the arachidonic acid metabolic pathway and BMJ 2003;327:55760. [Functions and Indications]Clear heat and detoxify, remove lung hotness. To clear scourge and remove toxin, diffuse the lung and discharge heat. Patients diagnosed with COVID-19 of all ages and racial groups will be included. Even if symptoms of fever, fatigue and cough end earlier, please continue to complete an 8-day course to help the body recover.For children younger than 14 years old, we recommend that you consult a TCM physician on the dosage since the body condition differs from each child. [Administration and Dosage] Ephedra was banned from the Olympics and other sport events, even in the US military. Medicine. LHQW is approved by China'sNational TCM Administration for the treatment of mild covid-19. [4]. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. WebDosage: 2 capsules twice a day ( after breakfast & dinner) >14 years & above: 4 capsules x 3 times a day ( after breakfast, lunch and dinner) for 7 to 10 days. Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. The manuscript was drafted by XLZ and MJL. China's top respiratory expert, the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. To consume within 2 weeks after opening. Treatment of Pediatric Diseases, 2017, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2016, the Phase II Clinical Trial for Lianhua Qingwen approved by US FDA started in Virginia in the US in September, 2015, recognized as a recommended product in the Expert Consensus Document on Treatment of Cold in Special Populations, 2015, recognized as a recommended product in the Standard Therapy for Middle East Respiratory Syndrome, 2014, recognized as a recommended product in the Standard TCM Therapy for Ebola Virus Infections, 2014, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Expert Consensus Document on Medical Rescuing of Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2012, recognized as a recommended product in the Standard TCM Therapy for Influenza B Virus Infections, 2011, recognized as a recommended product in the Guideline on Diagnosis and Treatment of Influenza, 2010, recognized as a recommended product in the Standard Therapy for Rheumatic Fever (Non-severe Community Acquired Pneumonia), 2009, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Influenza A H1N1, 2008, recognized as a recommended product in the Instructions on Use of TCM Therapies for Prevention and Treatment of Diseases after an Earthquake, 2008, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza (2008), 2005, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza, [Drug Name]Generic name: Lianhua Qingwen Capsules. In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group. 11. Bioinform Biol Insights. ACTSmarket.com is the e-shop and distribution arm of ACTSmarket Ltd, Led by Iloilos most respected journalists, the Daily Guardian pledges to tell the Ilonggo story as seen through the various lenses of society so that every side may be told. Therefore, it is necessary to carry out rigorous and objective quality evaluation for different types of clinical research, and the effectiveness analysis results obtained on this basis are more convincing. Since all the data included are published, the systematic review does not need ethical approval. sharing sensitive information, make sure youre on a federal Chinese herbal medicine 2008;31:12303. Clearing away heat toxic materials,open the inhibited lung-energy and clearing away lung heat. [27]. Philippines FDA approved LHQW for the treatment of mild Covid-19. Statistical analysis was conducted by Revman 5.3 software. Ends on 31 July 2022. At the same time, the single arm study was included in the analysis, not involved in data synthesis, only used to assist in displaying the clinical characteristics of the subjects, not for efficacy evaluation. Chunyuan Liu, Xiaoqiang Li, Shaoqian Cai. For the treatment of COVID-19, the main effects of Lianhua Qingwen are as follows: First, after taking the capsule, patients' symptoms improve quickly, two days earlier than the control group. Second, CT scan result also shows that patients recover faster than the control group. Third, the capsule can shorten fever time. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. [36]. The .gov means its official. 4 capsules per dose. If you are using other drugs, please consult your doctor before using this product. [29]. The clinical effective rate, CT improvement rate, and severe conversion rate will be assessed as the primary outcomes. Lianhua Qingwen capsule (granule) is an Innovative Patent Chinese medicine for the treatment of influenza, which was developed by the green channel of the new drug approval during the SARS period in 2003 based on the pathology of collateral of traditional Chinese medicine. Fish catch in Guimaras decreased by 29.6 percent from 7,844.53 metric tons in 2021 to 5,517 metric tons in 2022, as reported by the Chinese supplement Lianhua Qingwen: What you need to know, LOOK FOR BACKUP POWER: MORE Power assures 100% supply after weekend, Marcos prods NGCP to address energy woes in Western Visayas, Remains of two persons found dumped in concrete pipe, Guimaras fish yield down by 29.67% in 2022, DOE: Power reserves may run low in May, June, Globe secures ~P40.5B from its P91-B tower sale and leaseback, USTR keeps PH out of watchlist for 10 years, cites best, Iloilo taekwondo team hailed as overall champions in 2023 WVRAA meet, Gilas Pilipinas frontcourt woes continue as Aguilar & Erram ruled out, Kaya FC-Iloilo demolishes Mendiola FC in PFL clash, NBA Playoffs: Currys record-breaking 50-point Game 7 leads Warriors past Kings, Record-high 11,013 Filipino nurses took U.S. licensure exam for the first, Expert advice on identifying and treating allergic asthma, WHO and IAPAC sign a memorandum of understanding focused on ending, WHO launches new initiative to improve pandemic preparedness, 90% of countries report disruptions to essential health services since COVID-19 pandemic, Record-high 11,013 Filipino nurses took U.S. licensure exam for the first time in Q1, WHO and IAPAC sign a memorandum of understanding focused on ending epidemics in cities. Recently, the novel coronavirus pneumonia (COVID-19) epidemic has spread continuously and has been classified as class B infectious diseases (class a management). It includes forsythia, honeysuckle, ephedra (ma huang), armeniacae, gypsum, isatis, dryopteridis, houttuynia, pogostemon, rheum, rhodiola, Chinese peppermint (bohe), and liquorice. Infants / children aged below 4 years are not recommended to consume. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology[32] will be used to assess the quality of the evidence and risk of bias with on-line GRADE (https://www.gradeworkinggroup.org/).
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